Research Highlights

Neural Stem Cells Used to Reverse Multiple Sclerosis Symptoms and Promote Neurogenesis in Mouse Models

By:Shamim Gol Main Ideas/Background Multiple sclerosis is an autoimmune inflammatory disease that affects the CNS (central nervous system) of over 2.5 million people over the world. During the disease process, the individual’s own immune system attacks the oligodendrocytes present in the CNS. Oligodendrocytes are responsible for myelinating the neurons present in the CNS and when […]

Skin Organoids with Hair Follicles Grown Entirely from Human Pluripotent Stem Cells: A Potential Cure for Baldness?

By: Lomesh Choudhary & Anna Guinzbourg Main Ideas and Background Much research has been done over the years on skin-engineering, with scientists discovering that cells known as keratinocytes could be taken from the outer layer of skin (the epidermis), and grown in culture. Later, these sheets of newly grown keratinocytes could be transplanted back onto […]

Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration

  Main Ideas/Background Our skin acts as a tough barrier that protects us from the harsh outside environment. How does it do this? The skin is made up of many layers of epidermal cells which are constantly being regenerated, maintaining the skin barrier. Why are skin cells of interest to researchers? Their unique mechanism of […]

Human gingival fibroblast secretome accelerates wound healing through anti-inflammatory and pro-angiogenic mechanisms

  Background and Main Ideas Enhanced external wound healing currently remains an important medical priority. Recent studies have shown that the utilization of human gingival fibroblasts (hGFs) from oral mucosa show a significant reduction in wound area and inflammation as well as an increase in angiogenesis, collagen deposition and rate of re-epithelialization. (see figure in […]