By:Shamim Gol Main Ideas/Background Multiple sclerosis is an autoimmune inflammatory disease that affects the CNS (central nervous system) of over 2.5 million people over the world. During the disease process, the individual’s own immune system attacks the oligodendrocytes present in the CNS. Oligodendrocytes are responsible for myelinating the neurons present in the CNS and when […]
Research Highlights
Skin Organoids with Hair Follicles Grown Entirely from Human Pluripotent Stem Cells: A Potential Cure for Baldness?
By: Lomesh Choudhary & Anna Guinzbourg Main Ideas and Background Much research has been done over the years on skin-engineering, with scientists discovering that cells known as keratinocytes could be taken from the outer layer of skin (the epidermis), and grown in culture. Later, these sheets of newly grown keratinocytes could be transplanted back onto […]
Clinical Trials Show Promising Effects of Adipose-Derived Stem Cells in Treating Lymphedema
Lymphedema is a condition affecting one in three women who receive treatment for breast cancer. It is characterized by swelling which occurs from the buildup of fluid in the lymph nodes, often bringing lifelong discomfort to those suffering from it. However, a possible treatment has been found by Dr. Jogensen at Odense University Hospital. […]
Designer DNA therapeutic wipes out cancer stem cells, treats multiple myeloma in mice
Main Ideas and Background: Multiple myeloma is a blood cancer that has devastated many people, on account of its resistance to cancer treatments. However, a recent discovery by researchers at the University of California San Diego School of Medicine and Ionis Pharmaceuticals sheds light on the possibility of a new treatment that could target […]
Restoring metabolism of myeloid cells reverses cognitive decline in ageing
Main ideas, conclusion, background Maladaptive inflammation in the brain and other parts of the body causes cognitive decline and many diseases associated with aging. The main cause of this immune dysfunction is PGE2, which is a lipid messenger part of the COX-2 pathway, and it is responsible for modulating inflammation. The molecule is synthesized […]
Epidermal progenitors suppress GRHL3-mediated differentiation through intronic polyadenylation promoted by CPSF-HNRNPA3 collaboration
Main Ideas/Background Our skin acts as a tough barrier that protects us from the harsh outside environment. How does it do this? The skin is made up of many layers of epidermal cells which are constantly being regenerated, maintaining the skin barrier. Why are skin cells of interest to researchers? Their unique mechanism of […]
Human gingival fibroblast secretome accelerates wound healing through anti-inflammatory and pro-angiogenic mechanisms
Background and Main Ideas Enhanced external wound healing currently remains an important medical priority. Recent studies have shown that the utilization of human gingival fibroblasts (hGFs) from oral mucosa show a significant reduction in wound area and inflammation as well as an increase in angiogenesis, collagen deposition and rate of re-epithelialization. (see figure in […]